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KMID : 1137820150360040095
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의공학회지
2015 Volume.36 No. 4 p.95 ~ p.102
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Development of Real-time Closed-loop Neurostimulation System for Epileptic Seizure Suppression
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Kim So-Won
Kim Sun-Hee
Lee Y.-N.
Hwang S.-Y.
Kang Tae-Kyeong
Jun S.-B.
Lee Hyang-Woon
Lee Seung-Jun
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Abstract
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Epilepsy is a chronic neurological disease which produces repeated seizures. Over 30% of epileptic patients cannot be treated with anti-epileptic drugs, and surgical resection may cause loss of brain functions. Seizure suppression by electrical stimulation is currently being investigated as a new treatment method as clinical evidence has shown that electrical stimulation to brain could suppress seizure activity. In this paper, design of a real-time closed-loop neurostimulation system for epileptic seizure suppression is presented. The system records neural signals, detects seizures and delivers electrical stimulation. The system consists of a 6-channel electrode, front-end amplifiers, a data acquisition board by National Instruments, and a neurostimulator and Generic Osorio-Frei algorithm was applied for seizure detection. The algorithm was verified through simulation using electroencephalogram data, and the operation of whole system was verified through simulation and in- vivo test.
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KEYWORD
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neural recording, neurostimulation, epilepsy, closed-loop, real-time
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